Welcome to the course website
Using the navigation bar on the right, you can find links to reading, educational websites, videos, podcasts, weblinks and publications that you will find useful as you progress through the course
Selected course materials will also be posted on the University Moodle site.
Course Objectives
What will this course address?
This elective will examine the history and current challenges associated with the discovery, development and clinical use of antibiotics in medicine in an era of increasing multi-drug resistance. Specifically, the course will examine how (i) development of novel antibiotics has become more challenging in the last 30 years, (2) the key regulatory steps and barriers for advancing promising antibiotic candidates from the laboratory to clinical trials in humans, (3) the scientific basis underlying antibiotic dose selection an prediction of future resistance, and (4) clinical strategies for appropriate use for both older and newly-approved antibiotics. After completion of the course, medical biotechnology students will have a broad understanding of the key scientific issues and technologies used to address the greatest public health challenge of the 21st century-antibiotic resistance.
Course content
| Lecture | Topic | Hours |
|---|---|---|
| 1 | Introduction- History of antibiotic development | 2 |
| 2 | Antibiotic testing in the laboratory | 2 |
| 3 | Mechanisms and treatment strategies for antibiotic resistance- Part 1 | 2 |
| 4 | Mechanisms and treatment strategies for antibiotic resistance- Part 2 | 2 |
| 5 | Priority antimicrobial resistance pathogens: ESKAPE | 2 |
| 6 | Approaches towards antibiotic discovery-Part 1 | 2 |
| 7 | Approaches towards antibiotic discovery-Part 2 | 2 |
| 8 | Preclinical assessment of antibiotic candidates | 2 |
| 9 | Antibiotic toxicities | 2 |
| 10 | Antimicrobial susceptibility testing and clinical decisions | 2 |
| 11 | Clinical trial design and interpretation for antibiotic regulatory approval | 2 |
| 12 | Economics of antibiotic development and marketing | 2 |
| 13 | Diagnostic tests: Rationale application in antimicrobial therapy | 2 |
| 14 | Antimicrobial stewardship | 2 |
| 15 | Antibiotic development and access in low-middle income countries | 2 |
| 16 | Model-informed precision dosing and therapeutic drug monitoring | 2 |
Student Projects
Student evaluation
Contact information
All source material in this handout is cited or credited to the original source. All other un-cited images are public domain covered by Creative Commons Zero (CC0) license acquired though www.rawpixel.com.
